027: Dr. Dominic D’Agostino on Fighting Disease Through The Science of Keto

Oct 08

Dr. Dominic D’Agostino is an Associate Professor with tenure at the University of South Florida. Over the last ten years, the main focus of Dom’s lab has been to explore the science behind the ketogenic diet and ketone metabolite supplementation.

Dom teaches students of the Morsani College of Medicine and the Department of Molecular Pharmacology and Physiology on topics such as neuropharmacology, medical biochemistry, physiology, neuroscience, and neuropharmacology. He is also a Research Scientist at the Institute for Human and Machine Cognition (IHMC) to assist with their efforts towards optimizing the safety, health, and resilience of the warfighter and astronaut.

His laboratory develops and tests metabolic-based strategies for targeting seizures, epilepsy, neurodegenerative diseases, and cancer. He uses a variety of in vivo and in vitro techniques, including radio-telemetry (EEG, EMG), electrophysiology, fluorescence microscopy, confocal microscopy, atomic force microscopy (AFM), biochemical assays and in vivo bioluminescence imaging.

His current project is to identify the cellular mechanisms of seizures and to develop mitigation strategies against it. His efforts have focused specifically on measuring brain EEG, neuronal excitability, reactive oxygen species (ROS) production, and biomarkers of oxidative stress.

In this episode, Dominic D’Agostino talks about:

  • Studying medicine and finding keto
  • The effects of a ketogenic diet on epilepsy, neurodegenerative disease, and cancer
  • Ketones regulating gene expression + Kabuki Syndrome
  • Glucose Ketone Index
  • Macros for therapeutic ketosis
  • Ketogenic diet for anxiety
  • Additional therapeutic ketogenic resources

Featured Guest

Dominic D’Agostino
Dominic D'Agostino


Keto Nutrition’s Website
A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome
Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats
The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer
Dom D’Agostino, Ph.D.: ketosis, n=1, exogenous ketones, HBOT, seizures, and cancer (EP.05) Podcast
USF Health researcher joins NASA deep-sea mission
NEEMO 22’s Flickr Album

About the Author

Kate Jaramillo: Creator of Ketogenic Living 101, 102, Straight-Up Wellness & Keto Living Coach Certification. Wellness Advocate & Badass.